摘要
乙型肝炎病毒（HBV）是肝细胞癌（hepatocellular carcinoma，HCC）的主要病因，研究发现HBV基因变异与HCC的发生过程关系密切。本文从病因学方面对乙型肝炎病毒致肝癌的主要机制作一综述。HBV基因有4个开放读码区（s、C、P、X区），主要通过点突变、插入、截短变异等方式与HCC发生相关。
Chronic hepatitis B virus is the most common cause of hepatocellular carcinoma. This article summarizes the pathogenesis of HBV-related carcinogenesis and the viral and host factors that may increase the risk of HCC development. HBV has 40RFs （S,C,P,X）. The approach associated with HBV-related hepatocarcinogenesis includes point mutation, insertion mutation and deletion mutations.
出处
《国际外科学杂志》
2009年第4期269-272,共4页
International Journal of Surgery
关键词
乙肝病毒
基因变异
肝细胞癌
hepatitis B virus
genetic mutation
hepatocellular carcinoma
