CA125联合血浆纤维蛋白原检测在降低卵巢癌误诊率中的意义

Significance of Detecting Fibrinogen Combined with CA125 in Reducing Misdiagnosis of Ovarian Cancer

目的:探讨提高卵巢癌诊断率的更好检测指标。方法:测定并比较82例卵巢癌与75例卵巢巧克力囊肿患者的血小板计数(PLT)、血清CA125及血浆纤维蛋白原(FIB)水平。结果:82例卵巢癌患者PLT、血清CA125及FIB水平均较卵巢巧克力囊肿患者明显升高(P<0.01),卵巢癌患者血浆FIB水平与CA125呈正相关(P<0.01),联用CA125和FIB时阳性预测值明显高于单用CA125检测及联用CA125,PLT二联检测的阳性预测值,略低于联用CA125,FIB,PLT三联检测阳性预测值,而阴性预测值最高。结论:卵巢癌患者体内存在着异常的血液高凝与继发纤溶状态,FIB升高可能与卵巢包块的良恶性及预后有关,联用CA125和FIB检测能提高卵巢癌的诊断率,降低误诊率。

Objective：To study the variation of CA125 and fibrinogen in patients with ovarian cancer or chocolate cyst of ovary,and to explore its clinical significance.Methods：The levels of platelet count,serum CA125 and plasma fibrinogen were determined in 82 cases of ovarian cancer and 75 cases of chocolate cyst of ovary.Results：There were significantly increases about platelet count,CA125,and fibrinogen values in patients with ovarian caner than those of chocolatecyst of ovary（P〈0.01）.The level of fibrinogen positively correlated with CA125 in the patients of ovarian cancer（P〈0.01）.The positive predictive value in combination of CA125 and fibrinogen was significantly higher than CA125 alone or combination of CA125 and platelet count.But it was slightly lower than combination of CA125,platelet count and fibrinogen.Nevertheless the negative predictive value in combination of CA125 and fibrinogen was the highest in them.Conclusions：There exists an abnormal balance between hyper-coagulation and secondary increased fibrinolytic activity in patients of ovarian cancer.The measurement of fibrinogen is probably beneficial to differentiate benign ovarian tumor from malignancies and to predict its prognosis.The correct diagnostic rate of ovarian cancer before operation can be improved through evaluating with CA125 and fibrinogen together.