呋喃丹控释颗粒剂的制备及释药动力学

Preparation of Controlledrelease Granular Formulations of Carbofuran and Their Release Kinetics

用乙基纤维素、高岭土制备了呋喃丹控释颗粒剂．研究了控释颗粒剂Ｇ１、Ｇ２和常规颗粒剂Ｇ３释放呋喃丹的速率．常规制剂释放呋喃丹的速率比控释制剂释放呋喃丹的速率高得多．Ｇ２的释放速率比Ｇ１的释放速率高．释药动力学表明，Ｇ１在前５０％药物释放符合零级动力学，在整个释药过程中符合一级动力学．Ｇ２和Ｇ３释放呋喃丹符合一级动力学．

Controlledrelease formulations of carbofuran were prepared in ethylcellulose using kaolin as an filler. The rates of release of the carbofuran were studied. The result show that rate of release of the carbofuran is higher from the commercial gormulation than from the controlledrelease formulations, the rate of release of G2 formulation the is higher than that G1. The release kinetics of drug is described, G1 is in accordance with zeroorder kinetics for the first 50% of drug and with firstorder kinetics for the all G2 and G3 is accordance with firstorder kinetics.