大蒜素抗癌作用及其机制研究进展

Antitumor Action of Allicin and Its Mehanisms

大蒜素是大蒜中的主要生物活性成分,包含多种烯丙基有机硫化物。近年国内外的流行病学调查和实验研究表明,大蒜素对多种肿瘤均有明显抑制作用。其主要作用机制是通过影响肿瘤细胞调控基因表达、细胞周期及细胞内酶系等途径诱导肿瘤细胞凋亡。同时还与转基因肿瘤疫苗及抗癌药物协同作用,增强抗癌效果。本文就近年来大蒜素抗癌作用的研究进展作一综述。

Allicin is a major bioactive component of garlic, including allyl sulfides of many kinds. Allicin has a significant antitumor effect on many kinds of cancer as demonstrated in epidemiological studies in China and elsewhere. The primary functional mechanism has been described as affecting pathways of tumor cell apoptosis induced by regulating gene expression, cell cycles, terminal kinase and extracellular-signal-regulated kinase. In addition, through the combination of allicin treatment with gene modified tumor vaccine as well as antitumor drugs, the antitumor effect can be enhanced significantly. This paper reviewed and summarized recent research on these topics.