心血管系统生物学研究进展

Research Progress of Cardiac Systems Biology

在后基因组时代中,系统生物学是最受关注的领域之一。系统医学生物学是系统生物学的一个重要的分支和组成部分,主要研究的对象是人体、疾病和防治措施。由于心血管疾病突出的重要性,研究人员正致力于心血管系统生物学的研究。本文综述了心血管系统生物学主要的研究课题,总结了用以整合数据的方法和策略,心血管系统模型的类型和应用,建模的工具和标准,未来的发展方向,以及心血管系统生物学可能将面临的一些挑战。

Systems Biology is one of the most widely discussed fields among emerging post-genomic disciplines. Medical systems biology is an important component of systems biology. The goals of medical systems biology are gaining a complete understanding of human body in normal and disease states. Driven by the great importance of cardiovascular diseases, cardiac systems biology is improving rapidly. This review provides an overview of major themes in the developing field of cardiac systems biology, including some of the high-throughput experiments and strategies used to integrate the datasets, various types of computational approaches used for developing useful quantitative models, and successful examples, future directions of cardiac systems biology.