哺乳动物神经细胞的去分化及诱导

Dedifferentiation of Mammalian Neural Cells and Its Induction

去分化是近年来细胞生物学,特别是新兴的干细胞生物学领域一个倍受关注的课题。大量实验证明,哺乳动物神经系统中各类神经细胞(如神经元、Schwann细胞、星形胶质细胞、少突胶质细胞等)在适当条件下均可发生不同程度的以细胞幼稚化、重新进入细胞周期和获得多向分化的潜能为主要特征的去分化表现。本文就哺乳动物各类神经细胞的去分化及其诱导条件、对神经再生修复等的作用作一综述。

Dedifferentiation of cells has elicited a great deal of attention in the field of cell biology. A great quantity of studies have proved that many types of cells, such as neuron, Schwann cell, astrocyte, oligodendrocyte, etc. , within mammalian nervous system could dedifferentiate in different extent, featured in cell becoming immature, reentering cell cycle and regaining pluripotentiality. This review concerns on dedifferentiation of various types of cells within mammalian nervous system and inducing conditions, as well as its effect on neural regeneration.