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SUMO对NF-κB信号通路的调控作用 被引量:5

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摘要 核转录因子NF-κB是一种广泛存在于真核细胞内的,具有多向性、多功能的重要调节蛋白,与机体免疫应答、炎症反应,以及肿瘤的发生发展等多种生理病理过程相关。蛋白质翻译后修饰对NF-κB信号通路能起调控作用,而小泛素相关修饰物(small ubiquitin-related modifier,SUMO)是近年报道的参与调控NF-κB信号通路的一种非常重要的小分子蛋白,本文就SUMO对NF-κB信号通路的调节作用做一介绍。
出处 《生理科学进展》 CAS CSCD 北大核心 2009年第2期154-157,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30670409 30771221) 科技部(863计划)基金(2006AA02Z120)资助课题
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参考文献10

  • 1李淑晶,程智逵,伍会健.SUMO在转录中的抑制作用[J].中国生物化学与分子生物学报,2007,23(7):525-530. 被引量:12
  • 2肖利云,杨春华,邢欣荣,伍会健.SENP1与前列腺癌[J].中国生物化学与分子生物学报,2008,24(3):209-213. 被引量:9
  • 3Guo D, Li M, Zhang Y, et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet, 2004, 36 : 837 -841.
  • 4Huang TT, Wuerzberger-Davis SM, Wu ZH, et al. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell, 2003, 115 : 565 -576.
  • 5Mabb AM,Wuerzberger-Davis SM, Miyamoto S. PIASy mediates NEMO sumoylation and NF-KB activation in response to genotoxic stress. Nat Cell Biol, 2006, 8 : 986 - 993.
  • 6Wuerzberger-Davis SM, Nakamura Y, Seufzer B J, et al. NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene, 2007, 26 : 641 -651.
  • 7Wu ZH, Shi Y, Tibbetts RS, et al. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science, 2006, 311 : 1141 - 1146.
  • 8Liu B, Yang Y, Chernishof V, et al. Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. Cell,2007,129:1113 - 1123.
  • 9Liu B, Yang R, Wong KA, et al. Negative regulation of NF-κB signaling by PIAS1. Mol Cell Biol,2005, 25 : 1113 -1123.
  • 10Jang HD, Yoon K, Shin Y J, et al. PIAS3 suppresses NF- kappaB-mediated transcription by interacting with the p65/ RelA subunit. J Biol Chem, 2004, 279 : 24873 - 24880.

二级参考文献74

  • 1Treuter E,Gustafsson J A.Wrestling rules in transrepression:as easy as SUMO-1,-2,-3?[J].Mol Cell,2007,25(2):178-180
  • 2Cheng J,Bawa T,Leey P,et al.Role of desumoylation in the development of prostate cancer[J].Neoplasia,2006,8 (8):667-676
  • 3Hay R T.SUMO:a history of modification[J].Mol Cell,2005,18(1):1-12
  • 4Gill G.Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity[J].Curr Opin Genet Dev,2003,13(2):108-113
  • 5Yamamoto H,Ihara M,Matsuura Y,et al.Sumoylation is involved in β-catenin-dependent activation of Tcf-4[J].EMBO J,2003,22(9):2047-2059
  • 6Gomez-del Arco P,Koipally J,Georgopoulos K.Ikaros SUMOylation:switching out of repression[J].Mol Cell Biol,2005,25(7):2688 -2697
  • 7Verger A,Perdomo J,Crossley M.Modification with SUMO.A role in transcriptional regulation[J].EMBO Rep,2003,4(2):137-142
  • 8Poukka H,Karvonen U,J(a)nne O A,et al.Covalent modification of the androgen receptor by small ubiquitin-like modifier 1(SUMO-1)[J].Proc Natl Acad Sci USA,2000,97(26):14145-14150
  • 9Yang S H,Jaffray E,Hay R T,et al.Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity[J].Mol Cell,2003,12(1):63-74
  • 10Kim J,Cantwell C A,Johnson P F,et al.Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation[J].J Biol Chem,2002,277(41):38037-38044

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