期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

热休克因子1活性的调控机制 被引量：2

下载PDF
导出
摘要 热休克因子1(HSF1)是调控热休克蛋白(HSPs)表达的核心转录因子,可被热应激、氧化应激、缺氧/血、pH下降等刺激因素激活,与靶基因的热休克元件特异性结合,增强HSPs表达,发挥内源性保护作用。HSF1活性的调控发生在HSF1三聚化、转位入核、结合DNA和调节转录等多个环节,受到分子伴侣蛋白、磷酸化作用、氧化-还原等机制共同调控,其复杂而精确的调控对于应激应答、生长发育等过程有重要意义。
作者 杨勐航 吴畅 马骏 林丽
机构地区 第二军医大学生理学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2009年第2期175-178,共4页 Progress in Physiological Sciences
基金 国家重点基础研究项目(2006CB503807) 国家自然科学基金(30600763) 上海市浦江人才计划基金(08PJ14001)资助课题
关键词 热休克因子 转录因子 调控机制
分类号 Q256 [生物学—细胞生物学]
  • 相关文献

参考文献10

  • 1Akerfelt M, Trouillet D, Mezger V, et al. Heat shock factors at a crossroad between stress and development. Ann N Y Acad Sci, 2007, 1113 : 15-27.
  • 2Voellmy R, Boellmann F. Chaperone regulation of the heat shock protein response. Adv Exp Med Biol,2007,594 : 89-99.
  • 3Wigmore SJ, Sangster K, McNally SJ, et al. De-repression of heat shock transcription factor-1 in interleukin-6-treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1. Int J Mol Med, 2007, 19 : 413-420.
  • 4Guettouche T, Boellmann F, Lane WS, et al. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem, 2005, 6 : 4.
  • 5Wang X, Khaleque MA, Zhao M J, et al. Phosphorylation of HSFI by MAPK-activated protein kinase 2 on Serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem, 2006, 281 : 782 -791.
  • 6Seo HR, Chung DY, Lee YJ, et al. Heat shock protein 25 or inducible heat shock protein 70 activates heat shock factor 1 : dephosphorylation on serine 307 through inhibition of ERK1/ 2 phosphorylation. J Biol Chem,2006,281 : 17220 - 17227.
  • 7Shamovsky I, Ivannikov M, Kandel ES, et al. RNA-mediated response to heat shock in mammalian cells. Nature, 2006, 440 : 556-560.
  • 8Fossati S, Formentini L, Wang ZQ, et al. Poly (ADP-ribosyl) ation regulates heat shock factor-1 activity and the heat shock response in routine fibroblasts. Biochem Cell Biol, 2006, 84 : 703 -712.
  • 9Baird NA, Turnbull DW, Johnson EA. Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem, 2006, 281 : 38675-38681.
  • 10吴畅,任安经,袁文俊,林丽.热休克转录因子1的抗炎症作用[J].生理科学进展,2008,39(2):151-154. 被引量：4

二级参考文献10

  • 1Hashikawa N, Yamamoto N, Sakurai H. Different mechanisms are involved in the transcriptional activation by yeast heat shock transcription factor through two different types of heat shock elements. J Biol Chem, 2007,282 : 10333-10340.
  • 2Sakurai H, Takemori Y. Interaction between heat shock transcription factors (HSFs) and Divergent binding sequences: binding specificities of yeast HSFs and human HSF1. J Biol Chem, 2007, 282 : 13334- 13341.
  • 3Singh IS, He JR, Calderwood S, et al. A high affinity HSF- 1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-α gene is a transcriptional repressor. J Biol Chem, 2002, 277 : 4981 - 4988.
  • 4Tanaka KI, Namba T, Arai Y, et al. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem, 2007, 282 : 23240-23252.
  • 5Xie Y, Zhong R, Chen C, et al. Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms Genes. J Biol Chem, 2003, 278 : 4687 - 4698.
  • 6Wirth D, Bureau F, Melotte D, et al. Evidence for a role of heat shock factor 1 in inhibition of NF-κB pathway during heat shock response-mediated lung protection. Am J Physiol Lung Cell Mol Physiol, 2004, 287 : L953 - L961.
  • 7Chen Y, Currie RW. Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NF-KB and AP-1 in vascular smooth muscle cells. Cardiovasc Res, 2006, 69 : 66 - 75.
  • 8Chen Y, Arrigo AP, Currie RW. Heat shock treatment suppresses angiotensin Ⅱ-induced activation of NF-κB pathway and heart inflammation: a role for IKK depletion by heat shock? Am J Physiol Heart Circ Physiol, 2004, 287 : H1104 - H1114.
  • 9Chen Y, Currie RW. Heat shock treatment suppresses angiotensin Ⅱ-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. Inflamm Res, 2005, 54 : 338 - 343.
  • 10Knowhon AA. NF-κB, heat shock proteins, HSF-1, and inflammation. Cardiovasc Res, 2006, 69 : 7 - 8.

共引文献3

同被引文献18

引证文献2

二级引证文献1

生理科学进展
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部