血浆B型钠尿肽测定在诊断老年急性呼吸困难中的应用

Diagnostic value of plasma BNP concentration determination in elderly patients with acute dyspnea

目的探讨血浆BNP测定在诊断老年性急性呼吸困难中的应用。方法选择呼吸困难的老年患者共106例,选择正常对照组50例,用荧光免疫法快速测定BNP水平。结果对明确诊断的心源性呼吸困难患者51例和肺源性呼吸困难患者55例,进行回顾性分析,其血浆BNP水平分别为(843.12±432.12)pg/ml和(159.34±97.62)pg/m;对照组50例,其血浆BNP水平为(52.16±16.96)pg/ml。心源性呼吸困难患者与对照组及肺源性呼吸困难患者比较,其血浆BNP水平均有显著差异(P<0.01),肺源性呼吸困难患者与对照组比较,血浆BNP水平相对升高,有统计学差异(P<0.05)。结论血浆BNP水平测定对老年性呼吸困难的快速鉴别诊断具有较重要的意义。

Objective To observe the diagnostic value of plasma BNP concentration determination in elderly patients with acute dyspnea. Methods Plasma BNP levels were measured with fluorescence immunoassay in 106 elderly patients with dyspnea and 51 controls respectively. Results The plasma levels of BNP in patients with dyspnea from congestive heart failure （843.12 ±432. 12） pg/ml were significantly higher than those in patients with dyspnea from primary pulmonary origin （ 159. 34 ± 97.62 ） pg/ml （P 〈 0.01 ）, which in turn was higher than that in controls （52. 16±16. 96 ） pg/ml （ P 〈 0. 05 ）. Conclusion The rapid assay of plasma BNP concentration has important significance in rapid differential diagnosis in elderly patients with dyspnea.