肺血栓栓塞症患者血浆N-末端脑钠肽前体浓度的变化及临床意义

The clinical significance of plasma N-terminal pro-brain natriuretic peptide levels in patients with pulmonary thromboemboembolism

目的探讨肺血栓栓塞症(PTE)患者血浆N-末端脑钠肽前体(NT-proBNP)浓度的变化及临床意义。方法选择2007年1月至2008年5月在我院诊治的28例肺血栓栓塞症患者为观察组(其中3例随访),同期选择年龄、性别相匹配的健康者30名为对照组。采用酶联免疫吸附法(ELISA)检测血浆NT-proBNP浓度。结果观察组血浆NT-proBNP为1296±799 ng/L,对照组为350±240 ng/L,两组相比差异有显著性(P<0.01),其中3例有效治疗后血浆NT-proBNP分别由3142 ng/L、1049ng/L和1472 ng/L降至1554 ng/L、435 ng/L和662 ng/L。结论肺血栓栓塞症患者血浆NT-proBNP浓度升高,有效治疗后其浓度可能下降。观察血浆NT-proBNP浓度变化可能有助于PTE的诊断和疗效评估。

Objective To investigate the changes of plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） and its clinical significance in patients with pulmonary thromboembolism （PTE）. Methods The plasma NT-proBNP levels of 26 patients （ 14 males and 12 females, aged 66 ±12 y） with PTE admitted from Jan 2007 to May 2008 in Beijing Anzhen Hospital were analyzed retrospectively, among them 3 cases were followed up. Results The plasma NT-proBNP levels in patients with PTE were significantly higher than those in healthy controls （ 1296 ± 799 ng/l and 350 ± 240 ng/L, P 〈 0. 01 ）. Moreover the levels of 3 cases might decrease after the treatment. Conclusion The plasma NT-pro BNP levels in patients with PTE are high. It may be helpful in the diagnosis and effectiveness evaluation of pulmonary thromboembolism.