得力生联合化疗治疗晚期非小细胞肺癌

The Therapy of DLS combined with chemotherapy in stage Ⅲ-Ⅳ non-small cell lung cancer

目的观察广谱中药抗癌药得力生联合化疗治疗Ⅲ、Ⅳ期非小细胞肺癌的治疗效果和毒副反应。方法60例Ⅲ、Ⅳ期非小细胞肺癌患者随机分为A、B两组,A组采用得力生加GP方案化疗,B组采用单纯GP方案化疗。两组患者在治疗前后测定外周血T淋巴细胞亚群和NK细胞活性,评价患者疗效、免疫功能、生活质量及不良反应,并检测外周血血管内皮生长因子水平。结果治疗后A、B两组的有效率分别为50%和33%(P<0.05);A组的T淋巴细胞亚群和NK细胞活性明显高于治疗前(P<0.01),而B组无明显变化(P>0.05);A组的Karnofsky评分上升率(53%)高于B组(33%)(P<0.01);两组治疗后生存质量有显著性差异;A组的不良反应发生率低于对照组,且发生的程度较轻。结论得力生联合化疗治疗Ⅲ、Ⅳ期非小细胞肺癌的疗效优于单纯化疗,能增强机体免疫功能,改善患者的生存质量,且不增加骨髓抑制。

Objective DLS which is widely used in clinical has attracted great attention from both pharmacologists and clinicians as an anti-tumor agent. The aim of this study is to observe the therapeutic efficacy and toxicity of DLS combined with chemotherapy in stage Ⅲ-Ⅳ non-small cell lung cancer （ NSCLC ）. Methods Eighty-one patients with stage Ⅲ-Ⅳ NSCLC were randomly divided into two groups： ① group A ： DIS ＋ GP regimen ; ② group B ： Simple GP regimen. The peripheral blood T lymphocyte subsets and natural killer （NK） cell activity of patients in both groups were measured before and after treatment, while compared with healthy control （30 cases）. The immune functions, the effect oftreatment, quality of life, and adverse reactions were observed, vascular endothelial growth factor （VEGF）. Results The complete response and partial rate in group A and B was 50% and 33% respectively ,with insignificant difference between the two groups（ P 〈 0. 05 ）. Quality of life combining group wsas significantly higher than that in control group after treatment. The blood T cell levels and NK cell activity in group A increased （ P 〈 0. 01 ）, but ingroup B the value had no obvious change （ P 〉 0.05 ）. Quality of life in group A was higher than that in group B （ P 〈 0. 01 ）. The incidence of side effects in combining group was lower than that in control group, and the degree was also slighter. Conclusion The therapeutic effect of DLS combined with chemotherapy is better than that of chemotherapy alone. It can improve efficacy and the quality of life , and reduce side effect of chemotherapy, while promote hematopoiesis tanction.