卵巢癌患者手术治疗前后血清CA125、TNF-α和TSGF测定的临床意义

Clinical Significance of Determination of Changes of Serum CA125,TNF-α and TSGF Levels After Operation in Patients with Ovarian Cancer

目的:探讨了卵巢癌患者手术治疗前后血清CA125、TNF-α和TSGF水平的变化及临床意义。方法:应用放射免疫分析和生化法对33例卵巢癌患者进行了手术治疗前后血清CA125、TNF-α、TSGF测定,并与35名正常健康妇女作比较。结果:在手术治疗前血清CA125、TNF-α和TSGF水平均非常显著的高于正常人组(P<0.01)。手术治疗后6个月则与正常人比较无显著性差异(P>0.05)。结论:血清CA125、TNF-α和TSGF水平的测定对卵巢癌的诊断、疗效观察和预后评估均有重要的临床价值。

Objective To explore the clinical significance of changes of serum CA125, TNF - α, and TSGF levels after operation in patients with ovarian cancer. Methods Serum levels of CA125, TNF - α（with RIA） and TSGF （with bio chemistry） were determined in 33 patients with ovarian cancer both before and after operation and 35 controls. Results Before operation serum CA125, TNF -α and TSGF levels were significantly higher in the patients than those in controls （P 〈0.01 ）, Six months after operation, the levels were not significantly different from those in controls （ P 〉 0. 05 ）. Conclusion Detection of serum CA125, TNF - α and TSGF levels was useful for assessment of therapeutic efficacy and was of important clinical values in patients with ovarian cancer.