子宫内膜异位症患者治疗前后血浆ET-1、血清TNF-α和CA19-9检测的临床意义

Clinical Significance of Determination of Changes of Plasma ET and Serum TNF-α,CA19-9 Levels After Treatment in Patients with Endometriosis

目的:探讨子宫内膜异位症(EMS)患者治疗前后血浆内皮素-1(ET-1)、血清TNF-α和CA19-9水平变化及临床意义。方法:应用放射免疫分析对38例EMS患者进行血浆ET-1和血清TNF-α和CA19-9检测,并与35例正常健康妇女做比较。结果:在治疗前,患者血浆ET-1和血清TNF-α和CA19-9水平均非常显著地高于正常妇女组(P<0.01),经治疗3个月后则与正常妇女比较无明显差异(P>0.05),且血浆ET-1水平和血清TNF-α和CA19-9水平呈正相关(r=0.6118、0.6014,P<0.01)。结论:检测EMS患者血浆ET-1和血清TNF-α和CA19-9水平的变化对其病情和预后判断均有重要的临床意义。

Objective To explore the clinical significance of changes of plasma ET and serum TNF -α, CA19 -9 levels after treatment in patients with endometriosis. Methods Plasma ET and Serum TNF -α, CA19 - 9 levels were detected with RIA in 38 patients with endometriosis both before and after treatment and 35 controls. Results Before treatment, the plasma ET and serum TNF - α, CA19 - 9 levels were significantly higher in the patients than those in controls （ P 〈 0.01 ）. After treatment for 3 months, the levels were not significantly different from those in controls （P 〉 0.05）. There were significantly positive correlation between the levels of plasma ET and serum TNF-α, CA19-9 levels（r=0.6118,0.6014, P〈0.01）. Conclusion Determination of plasma ET and serum TNF- α, CA19 -9 levels in clinically useful in the management of patients with endometriosis.