COX-2与P73在胃癌中的表达及相关性探讨

Clinical Significance of Expression of COX-2 and P73 in Gastric Carcinoma Tissue

目的:探讨COX-2和P73在胃癌组织中的表达及临床意义。方法:应用免疫组化Envision法检测COX-2和P73在62例胃癌组织中的表达情况。结果:全组COX-2阳性率为64.5%(40/62),P73阳性率为69.4%(43/62)。COX-2的表达与组织分化程度、浸润深度、淋巴结转移和临床TNM分期相关(P<0.05);P73的表达与浸润深度、淋巴结转移和临床TNM分期相关(P<0.05)。COX-2和P73同时表达、单独表达及不表达时,胃癌的组织分化程度、病变浸润深度(T分期)、淋巴结转移(N分期)和临床分期组间差异有统计学意义(P<0.05)。COX-2和P73在胃癌组织中的表达具有相关性(r=0.384,P<0.05)。结论:胃癌组织中存在COX-2和P73基因的过度表达,COX-2和P73基因的过度表达与胃癌发生发展有关。

Objective To investigate COX -2 and P73 expression in gastric carcinoma tissue. Methods The expression of COX -2 and P73 in gastric carcinoma tissue were detected with immune -histochemistry （Envision method） in 62 resected gastric speciments Results The positive rate of COX -2 and P73 was 64.5% （40/62） and 69.4% （43/62）respectively. Significant correlations were observed between the expreasion of COX -2 and the clinical factors including degree of differentiation, depth of invasion （r = 0. 384, P 〈 0.05 ）, lymphaticmetastasis and TNM staging. There was significant correlation between the expression of P73 and the clinical factors including depth of invasion, lymphaticmetastasis and TNM staging. Among groups with （1） COX -2 or P73 positive only （2） both positive （3） both negative, differences of degree of differentition, TNM and clinical staging were all significant （P 〈 0.05）. The expression of COX - 2 was significantly correlatied positively with that of P73 in gastric carcinoma trssue（ r = 0. 384,P 〈 0.05）. Conclusion The results suggest that there is overexpression of COX -2 and P73 in gastric cancer tissue, which is prognestically significant.