类风湿性关节炎患者IL-6、IL-18和CRP的水平变化及意义

Clinical Significance of Changes of Serum IL-6,IL-18 and CRP Levels in Patients with Rheumatoid Arthritis

目的:研究类风湿性关节炎(RA)患者血清白细胞介素-6(IL-6)、白细胞介素-18(IL-18)和C-反应蛋白(CRP)水平的变化及其临床意义。方法:收集84例RA患者,以70例健康体检者作对照。采用双抗体夹心酶联免疫吸附法测定血清IL-6、IL-18和免疫荧光法测定CRP的水平,并测定血小板计数(Plt)、血沉(ESR)、类风湿因子(RF)。结果:RA患者的血清Plt、ESR、RF、IL-6、IL-18和CRP的含量明显高于健康对照组(P<0.01)。RA患者活动期上述指标含量(除RF外)均显著高于稳定期(P<0.01),Plt升高RA患者组与Plt正常组相比,RF、ESR、IL-6、IL-18和CRP水平均有明显统计学差异(P<0.05)。结论:IL-6、IL-18和CRP在RA患者的疾病发展过程中发挥着重要作用,它们的水平变化与RA患者病情有关,联合动态监测有助于临床观察RA患者的病情变化和治疗效果。

Objective To investigate the clinical significance of changes of serum interleukin -6 （IL -6）, interleukin -18 （IL -18） and C- reactive protein （CRP） levels in patients with rheumatoid arthritis （RA）. Methods Serum IL- 6, IL- 18 （with ELISA） and CRP （with immunofluroseense method） were determined in 84 patients with rheumatoid arthritis and 70 controls. The platalet count, ESR and serum rheumatoid factor （RF） were also examined. Results The platalet count, ESR, serum RF, IL -6, IL - 18 and CRP levels in patients with RA were significanlty higher than those in controls （ P 〈 0.01 ）. These parameters （ except RF） in patients with active RA were significantly higher than those in patients during stable stage （P 〈0.01 ）. RF was about the same during active and stable stages. The ESR and the levels of RF, IL - 6 ,IL - 18 and CRP were significantly higher in RA patients with high platelet count （n =36） than those in patients with normal platelet count （n =48） （P 〈0.05）. Conclusion IL -6, IL -18 and CRP play important roles in the development of rheumatoid arthritis. Monitoring the serum levels changes is helpful for assessment of disease process and therapentic efficacy.