腹腔镜手术联合米非司酮治疗子宫内膜异位症52例临床研究

Experience in combined laparoscopy and mifepristone for treatment of 52 patients with pelvic endometriosis

目的探讨腹腔镜手术与米非司酮联合治疗子宫内膜异位症的临床疗效。方法选择2005年3月至2006年8月在我院就诊的106例子宫内膜异位症术后患者，其中腹腔镜手术54例（A组）；腹腔镜手术联合米非司酮52例（B组），术后第3d口服米非司酮12．5mg，1次／d，连续3个月。所有患者随访3～12个月。结果随访率为97．17％（103／106），A组有效率为37．04％（20／54），B组有效率为59．62％（31／52）。B组疗效明显优于A组（P〈0．05）。B组患者只有2例转氨酶升高。结论腹腔镜手术联合米非司酮治疗子宫内膜异位症的疗效优于单纯腹腔镜手术，且不良反应轻，值得推广应用。

Objective To investigate the effect of combined laparoscopy and mifepristone in treatment of patients with pelvic endometriosis. Methods One hundred and six patients with endometriosis were treated in this hospital from March, 2005 to August, 2006, all these patients were randomly divided into simple operation group and combined therapy group containing 54 and 52 patients respectively. In the second group, mifepristone was administered in a dosage of 12.5 mg/d continuously for 3 months in each patient. All patients had been followed up for 3 to 12 months. Results The follow - up rate was 97.17% （103/106）. The effective rate of single operation group was 37.04% （ 20/54 ） , while it was 59.62% （ 31/52 ） in combined therapy group. It was much higher in second group than that of first group （ P 〈 0.05 ）. Elevation of serum level of transaminase was seen in 2 cases in combined therapy group. Conclusion The result of treatment for pelvic endometriosis in combined therapy group is superior to that of simple operation group with less side reactions. It is valuable to be recommended for clinical application.