加替沙星的吸附伏安特性及其应用研究

Absorptive voltammetric behavior of Gatifloxacin and the applications

目的研究加替沙星(Gatifloxacin,简称GTF)在汞电极上的电化学行为及其吸附伏安特性,为氟喹诺酮类其他药品的测定提供依据;方法:采用吸附溶出伏安法测定了GTF在汞电极上的电化学行为及相关参数;结果:测得GTF的饱和吸附量Гs=4.01×10-11mol·cm-2,每个GTF分子所占汞滴面积为2.02nm2,吸附系数β=1.08×106,25℃时的吸附自由能△Gθ=-29.14kJ·mol-1,电极反应电子数n=2,不可逆体系动力学参量αna=1.01,表面电极反应速率常量ks=0.27s-1;结论:测定了吸附溶出伏安法测定GTF的最佳条件,方法的检出限为2.0×10-8mol·L-1,重现性良好.

Objective： The electrochemical behavior and the absorption performance of the Gatifloxacin in the at Hg electrode is studied in order to provide a method for the detection of quinolone druggery. Method： The absorptive stripping voltammetry and the relative parameter of GTF at Hg electrode is detected by absorptive stripping voltammetry. Result： The saturated adsorption amount of GTF is 4.01×10^-11mol.cm^-2 An area occupied by each molecule is 2.02nm2 at Hg electrode. The absorption coefficient, β, is 1.08× 10^6 and the △G^θ is at 25℃. The number of electrons transferred, n, is 2. The kinetic parameter of the irreversible system is 1.01. Conclusion： A method for the detection of GTF is proposed by absorptive stripping voltammetry. The detection limit of the method is 2.0 × 10s mol.L^-1 under the optimized conditions. The repeatability is good.