细胞凋亡的信号传导通路及相关因子研究进展

Signal transduction pathways and the relative factors of apoptosis

细胞凋亡是细胞在各种死亡信号刺激后发生的一系列大量激活的主动性细胞死亡过程.细胞凋亡的信号传导主要有两条途径:受体依赖途径(外部途径)和线粒体途径(内部途径),两条途径互相交叉;死亡受体、死亡配体和半胱氨酸蛋白酶等细胞凋亡因子在两条途径中起核心作用.

Apoptosis is a series of numberous activated positive cell death procession responding to various kinds of cell death signal. Receptor-dependent （extrinsic） apoptotic pathway and mitochondrial-dependent （intrinsic） apoptotic pathways cross with each other, and both function in transduction of apoptosis. The factors involve in apoptosis, death receptor, death adaptor and Caspase, play crucial roles in the progress of programmed call death.