异甘草酸镁注射液治疗慢性乙型肝炎的疗效

Therapeutic effect of magnesium isoglyeyrrhizinate on chronic hepatitis B

目的观察异甘草酸镁对慢性乙型肝炎的疗效和安全性。方法选取慢性乙型肝炎病例178例,随机分成3组:异甘草酸镁大剂量组,给予异甘草酸镁200 mg;异甘草酸镁小剂量组,给予异甘草酸镁100 mg;甘草酸二铵组,给予甘草酸二铵150 mg。以上药品均加入5%葡萄糖250ml,静脉滴注,每日一次,疗程3周。结果异甘草酸镁大小剂量组的患者症状、体征的改善率以及肝功指标的好转程度显著优于甘草酸二铵组,且大剂量异甘草酸镁对慢乙肝的疗效优于小剂量异甘草酸镁。三组病人均未发现明显不良反应。结论异甘草酸镁对慢性乙型肝炎的疗效优于甘草酸二铵,且大剂量组疗效更好。

Objective To observe the therapeutic effects and drug safety of magnesium isoglyeyrrhizinate on chronie hepatitis B. Methods 178 patients of chronic hepatitis B were randomly divided into 3 groups, including high dose of magnesium isoglycyrrhizinate group（200mg of intravenous drop infusion administration）, low dose of magnesium isogly-cyrrhizinate group （lOOmg of intravenous drop infusion administration） and diammonium glycyrrhizinate group （150mg of intravenous drop infusion administration）. Results The improvement rates of symptom, clinical signs and liver function of magnesium isoglycyrrhizinate administrations was more obvious than that of diammonium glycyrrhizinate group. There was no serious adverse effect after treatment. Conclusion The therapeutic effect of magnesium isoglycyrrhizinate was better than that of diammonium glycyrrhizinate for chronic hepatitis B.