非酒精性脂肪肝与代谢综合征的相关性研究

Non-alcoholic fatty liver disease and metabolic syndrome

目的研究浙江省部分体检人群肥胖和代谢综合征（MS）的发病率，探讨非酒精性脂肪肝与代谢综合征及其组分的关系。方法选择在本院体检乙肝表面抗原阴性的3500例受检者，分别进行身高、体重、血压、丙氨酸氨基转移酶、血脂、血糖等生化指标检测及肝胆B超检查。结果非酒精性脂肪肝组的MS的患病率为25．49％，正常组MS的患病率为8．61％。两组比较差异有统计学意义（P〈0．05）。多因素回归分析非酒精性脂肪肝者患代谢综合征是对照组的3．927倍。非酒精性脂肪肝，体重指数和三酰甘油与代谢综合征显著相关。结论在浙江省部分人群中患非酒精性脂肪肝者，体重指数的增加和三酰甘油的升高是患代谢综合征的两个主要危险因素。

Objective To investigated the prevalence of obesity and metabolic syndrome （MS） and the relationship of non-alcoholic fatty liver disease （NAFLD） with MS in Hangzhou of Zhejiang province. Methods A total of 3500 subjects who were negative for hepatitis B surface antigen marker were selected to take physical examinations. Body height, body weight, blood pressure, alanine aminotransferase, fasting blood glucose, high-density lipoprotein cholesterol, and triglycerides were recorded. B-ultrasonography of the liver and gallbladder was undertaken. Results The prevalence of MS in the NAFLD or normal control group was 25.49% and 8. 61%, respectively （ P 〈 0.05 ）. In multivariate logistic regression analyses, MS patients were 3. 927 times more likely to be NAFLD-related. Increased body mass index （BMI） and triglyceride were significantly associated with NAFLD among MS patients. Conclusion BMI and triglyceride level may be the main risk factors of NAFLD-related MS.