急性脑梗死患者C-反应蛋白水平变化分析

Analysis of the changing of C-reaction protein level in patients with acute cerebral infarction

目的:研究血清C-反应蛋白(CRP)在脑梗死发病机制中的作用。方法:测定105例急性脑梗死(ACI)患者及98例健康对照者血清CRP含量,并根据梗死面积大小及神经功能缺损程度评分分组,分析各组与CRP水平的关系。结果:急性脑梗死患者平均CRP浓度为(10.81±3.46)mg/L,显著高于对照组的(5.18±1.33)mg/L,有非常显著性差异(P<0.01),小梗死灶组平均CRP浓度最低;中梗死灶组平均CRP浓度较小梗死灶组增高,有显著性差异;大梗死灶组平均CRP浓度最高,与小梗死灶组、中梗死灶组比较,有显著性差异。轻型组平均CRP浓度最低;中型组平均CRP浓度较轻型组增高,有显著性差异;重型组平均CRP浓度最高,与轻、中型组比较,有显著性差异。结论:急性脑梗死患者血清CRP水平随着病灶体积的增大和病情的严重程度而增加,CRP是可以评价脑梗死病情的严重程度和判定预后的一个敏感指标。

Objective：To investigate the function of serum C-reactive protein（CRP） in patients with acute cerebral infarction（ACI）.Methods：The contents of serum CRP in 105 patients with ACI and 98 normal controls were measured, the changes of CRP were compared with patients of different infarction size and scores of neurofunctional defect.Results：The level of CRP in patients with ACI was（10.81±3.46） mg/L, increasing significantly compared with control group of（5.18±1.33） mg/L（P〈 0.01）.The level of CRP in small infarction group was the lowest, middle infarction group was higher than the small group, and it showed a significant difference, large infarction group was the highest, and it showed a significant difference compared with small and middle group.The level of CRP of mild group was the lowest, middle group was higher than the mild group, and it showed a significant difference, serious group was the highest, and it showed a significant difference compared with mild and middle group.Conclusion：The levels of serum CRP increase along with the increase in size of infarction and severity of disease.CRP is a sensitive index for evaluating severity of disease and determining prognosis.