腹膜假黏液瘤的临床病理特征和预后分析

Analysis of the clinical and pathological characteristics and prognosis of pseudomyxoma peritonei

目的:探讨腹膜假黏液瘤的临床病理特点、病理诊断、发生及预后。方法:复习我院3例腹膜假黏液瘤患者的临床资料,对病理组织重新阅片和分型,对随访资料进行分析。结果:3例腹膜假黏液瘤男女比为1∶2,腹胀、腹部包块、腹围增大为其主要临床表现;1例术前有单侧卵巢黏液病变史,术后2年体健;2例伴有阑尾黏液性肿瘤,1例术后21个月复发,后2例均表现为腹腔大量黏液和腹膜多发包裹黏液性肿瘤;减瘤手术为主要的治疗方法,其他为辅助疗法。阑尾与腹膜假黏液瘤的发生可能有直接关系。结论:腹膜假黏液瘤具有独特的临床病理特点,影像学和腹腔穿刺对诊断具有提示意义,目前的治疗方法有待于完善,病理类型和生长速度是预后的影响因素,应对其加强认识。

Objective：To investigate the clinical and pathological characteristics, pathologic diagnosis, occurrence and prognosis of pseudomyxoma peritonei（PMP）.Methods：The clinical data of three cases of PMP in our hospital were reviewed, and the follow-up data were retrospectively analyzed.Results：In three cases, two were females and one was male, the main clinical presentation included bloating, abdominal mass and abdominal distention.One case had simple ovarian mucous tumor, two cases had appendix mucous tumor, one case had a relapse after operation about twenty one months.The latter two cases presented a large amount of abdomen mucus and peritoneal mucinous tumors.The most frequently practiced approach was debelking surgery of the main assistant means, the others were auxiliary therapies, and the appendix was closely related to PMR.Conclusion：PMP is a rare condition of borderline malignancy with its unique clinical and pathological characteristics.Imaging and abdominal paracentesis are very important to the diagnosis.The existed treatment measures need to be improved further, the pathological type and the growth speed of PMP are main factors which influence the prognosis.We must intensify this knowledge.