摘要
以戊二醛为交联剂制备了壳聚糖/果胶(CS-PT)水凝胶和壳聚糖/辛基果胶水凝胶。研究了制备条件对两种水凝胶溶胀性能的影响。实验表明,交联剂含量、pH、离子强度对CS-PT和壳聚糖/辛基果胶水凝胶溶胀度的影响较大,且在酸性条件下的水凝胶的溶胀度远大于碱性条件下的溶胀度,包埋在水凝胶中的牛血清蛋白在pH=1.0条件下载药的水凝胶释药率大于pH=7.4和pH=9.18条件下的释药率。
pH-sensitive hydrogels based on chitosan-pectin（CS-PT） and chitosan-octyl-pectin were synthesized by using glutaradehyde as cross-link agent. The effects of the degree of the dosage of crosslinking, pH, and ionic strength on the swelling behaviors of two kinds of hydrogels have been studied, and the swelling ratio（ SR ） of this hydrogel in acide solution is much larger than that in alkaline solution. The release behavior of bovine serum alumin entrapped in the hydrogels was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum alumin in those two kinds of hydrogels in the medium of pH = 1.0 was much quicker in pH = 7.4 and pH=9.18.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2009年第4期105-108,共4页
Polymer Materials Science & Engineering
关键词
壳聚糖/果胶水凝胶
溶胀度
牛血清蛋白
控制释放
chitosan-pectin hydrogel
swelling ratio
bovine serum alumin
controlled release
