右旋布洛芬缓释胶囊的释放度考察

The Delivery Test of Modified Release Capsule of Dex-ibuprofen

目的:考察右旋布洛芬缓释胶囊的释放度。方法:采用转篮法,溶出介质为pH6.0的磷酸盐缓冲液,对研制的右旋布洛芬缓释胶囊的三批样品的释放均一性和辅料、胶囊以及滤膜对释药的影响进行考察。结果:三批样品的各时段取样点的释放度相差不大,均匀度较好,均在规定的范围内;辅料、胶囊和滤膜对释药试验的结果没有干扰。结论:研制右旋布洛芬缓释胶囊释药稳定,其释放度测定法可以作为其质量控制的方法。

Objective：The delivery test of modified release capsule of Dex -ibuprofen. Methods：The delivery test of modified release capsule of Dex - ibuprofen had been done in buffer phosphate（pH6.0） by rolling basket,and investigate the effect by adjuvant, capsule and filter membrane to modified release capsule of Dex - ibuprofen. Results：The delivery test of modified release capsule of Dex - ibuprofen had no difference in three group samples and was not been able to change by adjuvant,capsule and filter membrane. Conclusion：The delivery test of modified release capsule of Dex - ibuprofen was stable and good and can control its quality.