不宁腿综合征40例临床分析

Clinical analysis of 40 patients of restless legs syndrome

目的探讨不宁腿综合征(RLS)的临床表现,观察吡贝地尔对RLS的治疗效果。方法对40例不宁腿综合征患者的临床特征和治疗结果进行回顾性分析。结果40例患者均有肢体不能忍受的不适感,迫切希望活动肢体,夜间症状加重,常伴失眠。根据国际不宁腿综合征研究组(IRLSSG)的诊断标准,平均得分24分。40例患者均给予吡贝地尔50mg睡前口服,治疗4周后,大多数患者主观症状明显改善,IRLSSG评分明显减少(平均得分11分)。结论不宁腿综合征常表现下肢不适,夜间加重,活动后减轻,常伴睡眠障碍,诊断主要依据临床表现,吡贝地尔治疗有一定效果。

Objective To explore the clinical manifestations of restless legs syndrome （RLS） ,and to observe the therapeutic effect of Piribedil. Methods The clinical manifestations and therapeutic results of 40 cases of restless legs syndrome were retrospectively analyzed. Results Forty patients all were accompanied with extremities discomfortableness that couldn＇t be able to tolerate, urged to move the extremities, and aggravated at night. The patients were frequently associated with insomnia. The average score was 24 according to the International Restless Legs Syndrome Study Group （IRLSSG） diagnostic criteria. All cases were given Piribedil 50rag at bedtime, after 4 weeks＇ treatment, the subjective ly symptoms were significantly improved in most patients, IRLSSG score significantly decreased （average score of 11 points）. Conclusion Restless legs syndrome often characterized by the lower extremity discomfortableness, night aggravated , postexercise relieved, and accompanied with dyssomnia. Restless legs syndrome is mainly diagnosed based on clinical manifestations, and Piribedil is effect.