蛋白质Z、蛋白质Z依赖性蛋白酶抑制物与卒中

Protein Z, protein Z-dependent protease inhibitor and stroke

蛋白质Z（protein Z，PZ）是一种维生素K依赖性蛋白，作为蛋白质Z依赖性蛋白酶抑制物（protein Z-dependent protease inhibitor，zai）的辅助因子，在磷脂和钙离子存在的条件下，能抑制凝血因子Ⅹa，使ZPI活性提高近1000倍，从而在血栓形成过程中发挥作用。ZPI可单独抑制凝血因子Ⅺa。ZPI的活性也在抑制凝血因子Ⅹa和Ⅺa的过程中被消耗。文章对PZ、ZPI的生物特性及与卒中的关联做了综述。

Protein Z （PZ） is a vitamin K-dependent protein. As a cofactor for the protein Z-dependent protease inhibitor （ZPI）, it inhibits coagulation factor X under the existence of phospholipid and calcium ion, and increases the ZPI activity by nearly 1000-fold, thus it plays a role in the process of thrombosis. ZPI inhibits coagulation factor Ⅺa alone. ZPI activity is also consumed in the process of inhabiting factor Ⅹ and Ⅺa. This article reviews the biological characteristics of PZ and ZPI and their association with stroke.