血清血脂分析结果与2型糖尿病患者视网膜硬性渗出的关系(英文)

Association of serum lipid profile with retinal hard exudates among patients with type 2 diabetes mellitus

目的:研究血脂分析结果与糖尿病性视网膜病之间的关系,以及2型糖尿患者合并其他系统疾病之间氧化低密度脂蛋白的关系。方法:横断面研究,包括40位糖尿病并糖尿病性视网膜病患者和40位糖尿病不并有糖尿病性视网膜病患者。收集人口学资料,进行详细眼科检查。空腹采集9mL静脉血,分析血清胆固醇,甘油三酯,高密度脂蛋白,低密度脂蛋白,氧化低密度脂蛋白和糖化血红蛋白。结果:糖尿病性视网膜病组平均血清胆固醇为5.9±1.86mmol/L,非糖尿病性视网膜病组为5.0±1.03mmol/L(P=0.001)。糖尿病性视网膜病组血清低密度脂蛋白为3.6±1.69mmol/L,而对照组为3.0±1.02mmol/L(P=0.005)。与轻至中度视网膜硬性渗出患者比较,重度视网膜硬性渗出患者血清胆固醇,甘油三酯和低密度脂蛋白较高,但是差异无统计学意义(P=0.082, 0.116, 0.218)。重度硬性渗出患者的平均血清氧化低密度脂蛋白较轻至中度者高。糖尿病病史长短以及是否合并其他系统疾病之间平均氧化低密度脂蛋白无统计学显著性差异。结论:血清胆固醇和低密度脂蛋白与糖尿病性视网膜病显著相关,而血清血脂分析结果与视网膜硬性渗出严重度不相关。我们研究发现,血清氧化低密度脂蛋白与糖尿病性视网膜病及合并的其他系统疾病之间无相关关系。

AIM ： To study the association between lipid profile and retinal hard exudates in diabetic retinopathy （DR） and the association between oxidized-LDL with systemic diseases among type 2 diabetic patients.METHODS：A cross sectional study was conducted in 40 patients with DR and another 40 patients without DR. Demographic data was collected and comprehensive ocular examination was performed. Nine mL venous blood was taken for fasting serum cholesterol, triglycerides, HDL, LDL, ox-LDL, and for HbA1c.RESULTS. The mean serum cholesterol level was 5.9± 1.86mmol/L in DR group compared to patients without retinopathy 5. 0±1. 03mmol/L （P=0.001）. The mean serum LDL was 3.6±1.69mmol/L in retinopathy group compared to 3.0±1.02mmol/L in the contol group （P= 0.005）. There was a higher concentration of serum cholesterol, triglyceride and LDL in patients with severe retinal hard exudates compared to those with mild and moderate, however it was not statistically significant （P=0.082, 0.116, 0.218） respectively. The mean serum oxidized-LDL concentration was higher in DR with severe retinal hard exudates compared to mild and moderate. There was no statistically significant difference in the mean oxidized LDL with other systemic diseases or duration of diabetes.CONCLUSION. There was significant association between serum cholesterol and LDL with DR. However there was no association between serum lipid profile with the severity of retinal hard exudates. Serum ox-LDL was also not associated with DR and other systemic co-morbidities in our study.