规范氧疗后早产儿视网膜病变的临床分析

Clinical analysis of the retinopathy of prematurity after criterion oxygen-treatment

目的:分析规范氧疗后早产儿视网膜病(retinopathy of prematurity,ROP)发生状况的特点。方法:回顾性分析2005-01/2007-12住院并符合筛选条件的早产儿277例的临床资料以及ROP筛查随访资料。结果:ROP发生率为5.4%,均为Ⅰ,Ⅱ期ROP,无Ⅲ期或以上的ROP;出生胎龄≤32wk的早产儿和出生体质量≤1499g的早产儿占93.3%;首次诊断ROP时患者32～37(34.7±1.4)wk;出生胎龄、出生体质量和氧疗时间是致ROP发生的高危因素(P<0.01)。结论:规范氧疗可降低ROP发生率,筛查主要对象是出生胎龄≤32wk且出生体质量<1500g的早产儿。

AIM： To analysis the changes of ROP development after criterion oxygen-treatment, and guide ROP prevention and treatment.METHODS： Retrospective analysing clinic and ROP screening data of 277 premature in-patients answered for the terms of case-choosing in our hospital from Januray 2005 to December 2007. RESULTS： The ROP incidence was 5.4%, and all ROP cases were at stage I or stage II, none were at stage 3 or above; The ROP colony consisted mostly of neonates with gestation-age ≤32 weeks and birth-weight 〈 1 499g （14/15, 93.3% ） ; The ROP first-diagnosis-time was from 32-37（34.7 ± 1.4） weeks after gestation; Gestation-age, birth-weight, oxygen-treatment time were still the high risk factors of ROP developing （P〈0.01）. CONCLUSION： Criterion oxygen-treatment can lower the ROP incidence, and is one of the ultimate measure- ments of ROP prevention; The ROP pathogenetic- condition tended to alleviate after criterion oxygentreat- ment; Under the situation of strict criterion oxygentreat- merit, neonates with gestation age ≤ 32 weeks and birth weight≤1 500g should be the most colony of ROP screening.