摘要
将2,3-环氧丙基三甲基氯化铵接枝到壳聚糖的氨基上制备了水溶性壳聚糖季铵盐(HTCC).讨论了反应物摩尔比、反应时间、反应温度和水用量等因素对季铵盐改性壳聚糖的取代度(DS)及反应效率的影响.通过红外光谱、核磁共振氢谱和化学滴定法对其结构进行了表征,同时测试了季铵盐改性壳聚糖对金黄色葡萄球菌的抗菌活性,与改性前壳聚糖相比,杀菌效果有了很明显地提高.
A water-soluble chitosan derivative, N-[ （2-hydroxy-3-trimethylammonium） propyl] chitosan chloride （ HTCC）, was prepared by introducing quaternary ammonium salt groups on the amino groups of chitosan. The influence factors of synthetic reaction, such as the molar ratio of reactants, time, temperature and an amount of water were discussed. The structure of this chitosan quaternary ammonium salt are characterized by FF-IR、1HNMR and chemical titration method. The antibacterial activities of quaternized chitosan against were explored. It was found that the antibacterial activity of quaternized chitosan against is much stronger than that of chitosan.
出处
《纺织高校基础科学学报》
CAS
2009年第1期85-89,共5页
Basic Sciences Journal of Textile Universities
关键词
壳聚糖
季铵盐
合成
改性
抗菌活性
chitosan
quaternary ammonium salt
synthesis
modification
antibacterial activity
