辅酶Q_(10)分子与几种重要生物膜分子的相互作用

The interaction between CoQ_(10) and several important biomembrane

用LB膜技术与原子力显微镜技术(AFM)研究辅酶Q10与磷脂酰胆碱、磷脂酰乙醇胺、胆固醇等几种重要的生物膜分子的相互作用.实验发现,PC(PE)分子膜中加入辅酶Q10后,相变均出现延缓,证明辅酶Q10位于疏水区,碳氢链伸入膜层当中,有可能起到抑制质子漏的作用.辅酶Q10与各重要生物分子的相互作用较为明显,辅酶Q10的加入增强了膜的通透性.

Based on LB technology and Atomic Force Microscope （AFM）, the interaction among CoQl0, phosphatidylcholine, phosphatidylethanolamine, cholesterol, GM, Sulfatidase and other important biomembrane was studied. The experiment shows that after adding CoQ10, PC（PE） staves off its changes while CoQ10 shows more obvious interaction with other important biomembrane.