血脑屏障与脑缺血再灌注损伤研究进展

Research Progress on Blood-Brain Barrier and Cerebral Ischemia-Reperfusion Injury

脑缺血再灌注损伤主要是指缺血脑组织恢复血液灌注后,脑组织损伤反而加重,表现为其神经损害体征和形态学改变有时会较前更加明显等。血脑屏障是存在于脑组织和血液之间的一个复杂的系统,能控制血脑两侧的物质转运,从而保证中枢神经组织内环境的相对稳定。血脑屏障的损伤在脑缺血再灌注损伤的发生及发展中起重要作用。多种因素参与了血脑屏障结构和功能的改变,而这些变化则是脑缺血再灌注损伤病理变化的重要环节之一。对影响血脑屏障改变的因素及其血脑屏障与脑缺血再灌注损伤之间的关系进行综述,为探讨脑缺血再灌注损伤的有效防治提供依据。

When the blood supply is restored, the aggravated damage of brain tissue is called the cerebral isehemiareperfusion injury. That presents more severer nervous defects and morphologic changes than earlier. The blood - brain barrier （BBB） is the regulated interface between the peripheral circulation and the central nervous system, which can keep the stability of internal environment of the central nervous system. The damage of BBB plays an important role in the oceurrenee of reperfusion injury and development. A number of studies have indicaded that many factors participated in the structural and functional changes of BBB during the process of cerebral isehemia reperfusion. The increase of BBB permeability is a key link in causing the pathological changes in reperfusion injury. To explore effective protective measures on reperfusion injury of cerebral ischemia,we review the infective factors of BBB and the relation between BBB and reperfusion injury in this article.