中医体质理论对慢性乙型肝炎诊治的启示

Illustration for Diagnosis and Treatment of Chronic Hepatitis B Relying on "Body Constitution Theory"

中医体质是个体生命过程中,在先天遗传和后天获得的基础上所表现出的形态结构、生理机能以及心理状态等方面综合的、相对稳定的特质,它决定着人体对某种致病因子的易感性及其病变类型的倾向性,又是决定病性、病位和病变趋势的重要因素。基因多态性是个体体质差异的分子学基础,多个基因产物间相互作用的结果是体质特征的根本反映。借助中医体质理论探讨乙肝患者的中医体质特点与相关基因表型间的内在联系可能对深入揭示HBV感染的发病机制、完善现有肝纤维化无创评估模型和判断预后、指导个体化治疗具有重要意义。

＂Body constitution of TCM＂ is a kind of composite idiosyncracy stably, which consists of morphosis, physiology and psychology on the basis of heredity and acception. ＂Body constitution of TCM＂ determines the susceptivity to pathogen, and influences the outcome of disease. The results of interactive gene products reflects the essence of＂ Body constitution of TCM＂, therefore, gene pulymorphism underlays the variability molecularly. According to this theory, we can find the intrinsic relationship between features of＂ Body constitution of TCM＂ and the correlated gene phenotype. Then, help to explore the pathogenesy of HBV infection, perfect the non - invasive model of liver fibrosis, estimate prognosis and direct the individualized treatment.