长期服用番泻叶提取物对雌性大鼠雌二醇水平的影响

The Impact of Senna Extract on Serum Estradiol(E_2) of Female Rats

目的:观察给予番泻叶水提物对雌性大鼠血清雌二醇(E2)水平的影响。方法:将40只Wiistar雌性大鼠随机分为5组,各剂量组分别给予相当于临床用药量的10、20、40、80倍。空白组给予等体积蒸馏水。连续灌胃3个月,每月最后一天测量体重并眼眶取血,分离血清并以放射免疫(RIA)技术检测血清E2含量水平。结果:第60天80倍剂量组血清E2水平较空白组显著升高(P<0.05),第90天时20、40、80倍剂量组血清E2水平均见显著升高(P<0.05或0.01)。结论:长期大量服用番泻叶会导致血清E2水平明显上升。

Objective ：To observe the role of senna extract on female rats＇ serum estradiol（ E2 ） after the long-term ad- ministration. Methods ：40 Wiistar female rats were divided into five groups, the dose groups were given 10,20,40,80 times as the normal administration of the medication women. Blank group was given equal volume of distilled water. After feeding 30d,60d ,90d,get the blood by orbital. Detecting the amounts of serum estradiol（ E2 ）by RIA. Results：The level of serum E2 from high-dose group had significantly increased（P 〈 0. 05 or 0. 01 ） and was positively related with the dose. Conclusion：Taking large doses of senna extract long-term can elevate the level of serum E2.