“五黄汤”对兔静脉炎疗效研究

The Effect of Wuhuang Tang on Phlebitis in the Rabbits

目的:探讨清热、活血、扶正经验方"五黄汤"在组织、细胞水平对静脉炎的干预,为临床推广提供依据。方法:选用4月龄大耳新西兰雄性白兔50只,通过静脉注射0.9%氯化钠注射液并保留静脉留置针120～168h,造成兔双耳外耳缘静脉不同程度的静脉炎。每只兔双耳随机分为观察组和对照组,分别用"五黄汤"和33%硫酸镁湿敷,每天换药2次,5天后取活体标本2cm×1cm,光学显微镜下观察血管病理学变化。结果:在Ⅰ级和Ⅱ级静脉炎治疗中:两组疗效相当,差异无显著意义(P>0.05),而在Ⅲ级静脉炎治疗中观察组疗效明显优于对照组,差异有显著意义(P<0.05)。在对血管血栓栓塞和炎症细胞浸润的改善方面,观察组明显优于对照组(P<0.05)。结论:"五黄汤"是临床治疗静脉炎的有效验方,疗效优于硫酸镁,是值得推广的中药方剂。

Objective： to observe the influence of Wuhuang Tang, which attenuate, promote blood flow. strengthen body resistance,on the tissue and cell in phlebitis rabbits and provide the evidence of treating phlebitis with the traditional medicine. Methods：50 four-month New-Zealand male rabbits＇ears were randomized into two groups： observed group and control group. Different degrees of rabbits-ears＇phlebitis were made by keeping integrated catheter into vein for 120h to 168h and injection of 30mL NS every day. Observed group was treated with Wuhuang Tang, however control group was treated with 33 % magnesium sulfate twice a day for five days. After five days of treatment, we took 2cm × 1 cm vein of rabbits-ears＇phlebitis and observed its pathological change by light microscope. Resuls：After treatment, there is no difference of inflammatory cell and red cell count in vessel wall or lumens in grade Ⅰor grade Ⅱ phlebitis between observed group and control group（P 〉 0. 05 ）, however in grade Ⅲ phlebitis, effect of observed group is better than that of control group significantly（P 〈0. 05 ）. The improvement of vessel thrombotic embolism and inflammation cell infiltration in observed group is better than that in control group. Conclusion ：Therapeutic effect of Wuhuang Tang is better than that of 33% magnesium sulfate. It is worth applying to clinical treatment.