补肾活血方配合髓芯减压术对早期股骨头缺血性坏死患者血液流变学的影响

Effect of Bushen Huoxue Decoction Combination Core Depression Operation on the Hemorheology of Patients with Avascular Necrosis of the Femoral Head

目的:观察补肾活血方配合髓芯减压术对早期股骨头缺血性坏死患者血液流变学的影响。方法:将125例Ⅰ期股骨头缺血性坏死患者随机分为治疗组63例,对照组62例,对照组采用髓芯减压术治疗,治疗组在髓芯减压术基础上,加服中药补肾活血方,连续用药3个月后观察两组患者治疗前后血液流变学变化,并判断临床疗效。结果:治疗组临床总有效率为87.3%,对照组临床总有效率为59.7%,两组具有统计学差异(P<0.01)。两组治疗后全血高切黏度、低切黏度、血浆比黏度、纤维蛋白原含量均较治疗前显著降低(P<0.01),其中治疗组治疗后全血低切黏度、血浆比黏度均明显低于对照组(P<0.01或P<0.05)。结论:补肾活血方联合髓芯减压术治疗早期股骨头缺血坏死优于单纯髓芯减压术,该作用可能与该药的改善血液流变学的作用有关。

Objective ：To observe the effect of Bushen Huoxue decoction Combination core depression operation on the hemorheology of patients with avascular necrosis of the femoral head. Methods ： 125 cases of avascular necrosis of the femoral head were devided into two groups randomly,and the treatment group（n =63）was treated with Bushen Huoxue decoction for oral use combination core depression operation,and the control group（n =62） was treated with core depression operation,to observe the hemorheology before and after treatment and therapeutic effect after three mothes of treatment. Results ： The effective rate of treatment group was 87.3% ,which was higher than that of control group（59. 7% ,P 〈0. 01 ）. Compared with before treatment, the home-shear and hyp-shear viscosity, specific viscosity of blood plasma and fibrinogen were decreased obviously in two groups（P 〈0. 05 of P 〈0. 01 ） ;The homo -shear and hyp-shear viscosity and the specific viscosity of blood plasma were different obviously in treatment groups （P 〈 0. 05 or P 〈 0. 01. Conclusion ：The therapeutic effect of Bushen Huoxue decoction combination core depression is super to that of core depression ,and the fuction were relative to improve hemorheology.