头孢克肟活性酯(mica酯)的合成

Preparation of Cefixime Active Ester

头孢克肟（Cefixime）是第三代口服头孢菌素。我国已经将头孢克肟列入“九五”及2010年医药科技发展规划中．头孢克肟传统合成方法有以下两种：一种以7-ACA为原料，与水杨醛缩合后经过酯化、氯化等反应制得：另一种以脱乙酰头孢菌素C为原料，经过酰化、氯化等反应制得。这两种合成方法因技术路线长、成本高及三废污染问题影响了该产品的扩大生产。

Cefixime has become the third generation of oral cephalosporin.The economic analysis and feasibility of the route for synthesizing cefixime from active ester of cefixime was summarized in this article.The confirmation and optimization of technical conditions for synthesis of active ester of cefixime from side chain MICA acid with refined DM were carried out.The suitable reaction conditions are obtained through optimization of reaction temperature,comparison of reactants and the drying conditions.Under the optimized conditions the yield of final product can be reached up to 81%.