连翘化学成分的研究

Studies on Chemical Constituents in Forsythia suspensa (Thunb.) Vahl

目的研究木犀科植物连翘[Forsythia suspensa(Thunb.)Vahl]果实的化学成分。方法利用DiaionHP-20、Toyopearl HW-40、Sephadex LH-20等凝胶色谱方法,用波谱学方法鉴定其化合物的结构。结果从连翘果实50%丙酮提取物的水部位分离得到9个化合物。分别为异落叶松脂素(Ⅰ),异橄榄脂素(Ⅱ),异落叶松脂素-4-O-β-D-葡萄糖苷(Ⅲ),异落叶松脂素-9'-O-β-D-葡萄糖苷(Ⅳ),calceolarioside B(Ⅴ),3,4-二羟基苯乙基-8-O-β-D-葡萄糖苷(Ⅵ),咖啡酸甲酯(Ⅶ),对羟基苯乙酸甲酯(Ⅷ),L-鼠李糖(Ⅸ)。结论其中化合物Ⅱ～Ⅸ均为首次从本属植物中分得。

OBJECTIVE To study the chemical constituents from Forsythia suspensa （Thunb.）Vahl. METHODS The chemical constituents were isolated and purified by Diaion HP-20, Toyopearl HW-40, Sephadex LH-20 column chromatography, and their structures were identified by physiochemical properties and spectral analysis. RESULTS Nine compounds were isolated from the water soluble fraction of the 50% aqueous acetone extract, they were identified as isolariciresinol （ Ⅰ ）, isoolivil （Ⅱ）, isolarieiresinol-4-O-β-D-glucopyranoside （Ⅲ）, isolariciresinol-9′-O-β-D-glucopyranoside （Ⅳ）, calceoladosideB （Ⅴ）, 3,4-dihydroxyphenylethyl-8-O-β-D-glucopyranoside （Ⅵ）, caffeic acid methyl ester （Ⅶ）, p-hydroxyphenylacefic acid methyl ester （Ⅷ）, L-rhamnose （Ⅸ）. CONCLUSION Compounds Ⅱ -Ⅸ were obtained from this genus for the first time.