336例宫颈病变液基细胞学和组织病理学的对比分析

Contrast analysis of liquid-based cytology and histopathology for 336 cases of cervical lesions

目的:评价液基细胞学(LCT)与组织病理学诊断结果的阳性符合率及其在宫颈病变筛查中的应用价值。方法:对分级在不典型鳞状上皮细胞(ASC)以上并追踪到组织病理学诊断的336例宫颈细胞涂片的诊断结果进行对照分析。结果:336例LCT诊断ASC135例,低度鳞状上皮内病变(LSIL)156例,高度鳞状上皮内病变(HSIL)39例,鳞状细胞癌3例,非典型腺细胞2例,腺癌1例;ASC中,意义不明确的不典型鳞状上皮细胞123例,不典型鳞状上皮细胞不除外高度鳞状上皮内病变12例;与组织病理学诊断结果进行对照,阳性符合率分别为癌100%,HSIL92.31%,LSIL69.87%。结论:LCT在宫颈病变的筛查中起重要作用。将患者临床资料进行综合分析对做出正确的细胞学诊断具有重要意义。

Objective：To evaluate the efficacy of liquid-based cytology test （LCT）for cervical cancer screening. Methods： LCT diagnosis of 336 cases with abnormal cervical cytologic results were compared with histopathology diagnosis.Results：LCT diagnosis of 336 cases included 135 cases of atypical squamous cells（ASC）,156 cases of low-grade squamous cervical intraepithelial lesion （LSIL）,39 cases of high-grade squamous cervical intraepithelial lesion（HSIL）,3 cases of squamous cell carcinoma,2 case of atypical glandular cells and 1 case of adenocarcinoma.The conformity rate of LCT and histopathology diagnosis was 100% in cancer,92.31% in HSIL,69.87% in LSIL.Conclusion：LCT plays a major role for screening of cervical lesions. Comprehensive analysis of the clinical data is important for confirmation of LCT diagnosis.HPV-DNA test combined with LCT is benefit to improve the confirmation of histopathology.