非糖尿病患者的冠脉病变程度与血清脂联素、尿微量白蛋白的相关性

Relationship among severity of coronary artery pathologies,serum adiponectin and urine micro albumin in coronary heart disease patients without diabetes mellitus

目的:通过测定非糖尿病的冠心病患者血清脂联素(APN)、24h尿微量白蛋白(UmAlb),探讨二者与冠脉病变程度的关系。方法:将137例进行冠脉造影检查的非糖尿病患者分为正常对照组、单支病变组、双支病变组和多支病变组。采用免疫比浊法测定尿白蛋白浓度,并根据尿量计算24hUmAlb,应用自动生化仪测定空腹血糖、高敏C反应蛋白(hsCRP),ELISA法测定血清APN。结果:冠心病患者各亚组随着冠脉病变程度的增加,hsCRP、UmAlb增加,APN水平下降。结论:血清APN和UmAlb与冠脉病变程度密切相关。

Objective：To investigate the relationship among severity of coronary artery pathologies,serum adiponectin （APN）and urine microalbumin （UmAlb）in coronary heart disease （CHD）patients without diabetes mellitus.Methods：One hundred and thirty seven patients without diabetes mellitus undergoing coronary angiographies were divided to no vessel pathology group （C）,single vessel pathology group （S）,double vessel pathologies group（D）and multiple vessel pathologies group（M）.UmAlb concentration was measured by immunoturbidimetry and calculated in 24 hours according to total volume of 24 hours＇ urine.Measuring fasting blood glucose,serum high sensitivity C-reactive protein （hsCRP） by automatic biochemical analyzer,measuring APN by ELISA.Results：There were no significant difference of the above items among the group C,S,D and M. With deterioration of the severity of coronary artery pathologies,hsCRP, UmAlb were increased and APN was declined.Conclusion：Serum APN and UmAlb were closely related to CHD.