结节性红斑与硬结性红斑皮损原位抗原研究

Study of in situ antigen in lesions of erythema nodosum and erythema induratum

采用PAP法对结节性红斑、慢性游走性给节性红斑、硬红斑及结节性血管炎4种疾病共35例的原位抗原进行检测。结果在血管的检出例数分别为11／12，8／8，8／8，6／7；在胶原纤维表面的检出例数分别为11／12，7／8，8／8，6／7；所有病例表皮角朊细胞内均能检出；在血管腔内与血管腔外的红细胞表面的检出例数除慢性游走性结节性红斑为5／8外，其余病种均能检出。提示结节性红斑等4种疾病均为存在免疫复合物疾病，具有共同的免疫病理基础，而且还提示免疫复合物在机体内处于动态清除过程之中。除红细胞转运降解以外还通过表皮以经皮排异形式从皮肤排出体外。

In situ antigens were detected with PAP method in skin biopises from 35 patients with erythema nodosum. chronic migrant erythema nodosum, erythema indura tum and nodular vasculitis. The results showed that the positive cases in the vessels of skin biopsies from the 4 kinds of disease were 11/12. 8 /8. 8 /8. 6/7 respectively: the positive cases on the surface of collagen fibers were 11/12- 7/8. 8 /8, 6/7. respee tively; All ('ases were positive in the keratinocytes of epidermis and the intra - luminal and extra-luminal erythrocytes surface of all cases were detected except that the positive cases from chronic migrant erythema nodosum were 5/8. These results suggest that all the four diseases are immune complex deseases, which have common immunopathologic basics. The results also reveal that immune complexes are in the process of dynamic elimination. Partial immune complexes may be excreted through epidermis by the mode of transepithelial elimination except that immune complexes are degraded through ery throcytes transportation.