摘要
目的观察赖氨匹林和阿斯匹林的镇痛作用。方法小鼠扭体法及热板法。结果赖氨匹林ig给药2种剂量(90.4及180.8mg·kg-1)对小鼠热板法中的痛反应潜伏期均有延长作用,可显著提高小鼠痛阈。赖氨匹林ig给药3种剂量(45.2,90.4及180.8mg·kg-1)均可明显减少小鼠扭体反应次数。赖氨匹林icv给药也具有明显的镇痛作用。结论赖氨匹林有较好的镇痛作用。
Objective To study the analgesic effect of lysine acetylsalicylate (LAS) and acetylsalicylic acid (ASA) in mice. Methods Hotplate and writhing test in mice were applied. Results LAS at two doses of 904 and 1808 mg·kg-1, ig, prolonged pain latency on hotplate reaction, and it also suppressed the times on writhing reaction at three doses of 452, 904 and 1808 mg·kg-1, ig. With injection of i.c.v. at 05 and 10 mg·kg-1 doses, LAS reduced the times on writhing reaction in mice. Conclusion LAS had the better analgesic effect.
出处
《安徽医科大学学报》
CAS
1998年第2期100-101,共2页
Acta Universitatis Medicinalis Anhui
关键词
药理学
阿斯匹林
赖氨匹林
镇痛
比较
lysine/ pharmacol
ASA/pharmacol
pain/therapyFree words LAS
analgesia