卡介苗联合白细胞介素-2膀胱灌注预防膀胱癌复发机理的研究

Mechanism of preventing the recurrence of bladder carcinoma by intravesical instillation of BCG plus

目的探讨卡介苗（ＢＣＧ）联合白细胞介素－２（ＩＬ－２）膀胱灌注预防膀胱癌复发的机理。方法对３５例膀胱移行细胞癌术后患者分别行ＢＣＧ和ＢＣＧ加ＩＬ－２膀胱灌注，随访１４～２２个月，复发率分别为３１．２５％和２１．０５％。结果应用ＩＬ－２加ＢＣＧ膀胱灌注６周后，外周血天然杀伤细胞激活因子（ＮＫＣＦ）活性明显增强，在ＮＫＣＦ活性与ＩＬ－２活性间有显著正相关变化。结论ＩＬ－２加ＢＣＧ膀胱灌注预防膀胱癌复发作用明显优于单纯用ＢＣＧ，ＩＬ－２和ＢＣＧ两者间有免疫促进和协同作用。

Objective To study the mechanism of preventing the recurrence of bladder carcinoma by intravesical instillation of BCG plus IL 2. Method Intravesical instillation of BCG or BCG plus IL 2 were carried out in the bladder transitional cell carcinoma patients undergoing surgical operation(16,19 cases respectively). Result They were followed up for 14￣22 months.The recurrence rates were 31 25% and 21 05% respectively. At 6 weeks after the instillation of IL 2 plus BCG,the peripheral blood NKCF activity was increased significantly and there was a significant positive correlation between the activities of NKCF and IL 2. Conclusion The intravesical instillation of IL 2 plus BCG is clearly superior to only BCG in preventing recurrence of bladder carcinoma.There may be immuno enhancement and immuno synergism.