HBeAg阴性慢性乙肝病毒携带者临床、肝脏病理、血清学检查五年回访

5 years dynamic observation and research on HBeAg negative chronic HBV carriers with regard to the clinical symptom,running liver biopsy and serological examination

目的了解HBeAg阴性慢性乙肝病毒携带者的转归。方法对52例HBeAg阴性慢性乙肝病毒携带者进行了为期5年的临床症状、肝活检及血清学检查的动态观察研究。结果5年间,52例HBeAg阴性慢性乙肝病毒携带者中有12例出现临床显性发病,约占总数的23.1%。其中13例行2次肝活检,原肝组织正常者几年内相对稳定,病理很少变化,原有病理改变者不易恢复。HBsAg年转阴率为1.2%。结论HBeAg阴性慢性乙肝病毒携带者肝脏病理极大多数有异常,临床是否发病与肝脏炎症分级密切相关。

Objective To understand the turnover of chronic asymptomatic carriers with HBsAg negativity. Methods A 5 year dynamic observation and research on 52 chronic asymptomatic carriers with HBsAg negativity has been taken via vie- wing the clinical symptom, running liver biopsy and serological examination. Results 12 of 52 patients, accounting for 23.1% , showed dominance morbidity. 13 patients received liver biopsy for the second time. We find that whose pathology of hepatic tissue was normal kept stable for several years while abnormal ones could hardly get recovery. The HBsAg darke- ning rate per year is 1.2%. Conclusion The pathology of liver tissue for most chronic asymptomatic carriers with HBsAg negativity is abnormal, and whether falling to clinical ill is reievant to the classification of liver inflammation.