原发性甲状腺机能减退症患者血清甲状腺激素自身抗体放射免疫法测定

Measurement and Clinical Significance of Thyroid Hormone Autoantibodies by Radioimmunoassay in Patients with Hypothyroidism

了解临床甲减病人血中甲状腺素自身抗体（T4Ab）及3，5，3'-三碘甲状腺原氨酸自身抗体（T3Ah）分布状况。方法：采用放射免疫法测定120例原发性甲减患者的T3Ab、T4Ab。结果：甲减患者T3Ab、T4Ab的测定值分别为9．42±4．43％及10．73±4．67％．较正常组升高非常显著（n=120．P＜0．01）；其T3Ab、T4Ab的阳性率分别为37．50％及40．83％。对甲减分组，伴TGAb和（或）TMAb升高组的T3Ab、T3Ab测定值及阳性率均较不升高组显著升高（P＜0．01）。结论：T3Ab、T4Ab在原发性甲减患者血中阳性率较高．其测定有助于甲减的诊断。

Objective To investigate the prevalence of anti-triiodothyronine antibody(T,Ab) and anti-thyroxine antibody(T.Ab) in patients with hypothyroidism and explore their clinical significance. Methods: T3Ab andT4Ab were measured in 120 patients with hypothyroidism by radioimmunoassay. Results: The levels of T3Ab andT4Ab were 9. 42± 4. 43 % and 10. 73±4. 67 % respectively, which were significantly higher than those in normal controls(n= 120,P<0. 01 ). The positive rates of T3Ab and T4Ab for patients with hypothyroidism were37. 5% and 40. 83% respectively. The levels and positive rates of thyroid hormone autoantibodies in patientswith increased antithyroglobulin antibody(TGAb) and /or antimicrosomal antibody(TMAb) were significantlyhigher than those with normal TMAb and TGAb(P<0. 01 ). Conclusion:The POsitive rates of T3Ab and T.Abin hypothyroidism are high and the measurement of T3Ab and T4Ab may be helpful for diagnosis of hypothyroidism.