PLGA组织工程支架材料在生理盐水中的降解性能

Degradable Performance of PLGA Tissue Engineering Scaffolds in NaCl Water Solution

本文利用红外漫反射仪、DSC测试,并通过对PLGA组织工程支架在生理盐水中的失重率、分子量以及生理盐水pH值变化的研究,发现:孔径在200-300微米的PLGA组织工程支架,在37℃,振荡速度为160r/min的生理盐水中,随着降解时间的延长,分子量不断减小;随着降解时间的延长,支架重量有升有降,但长期呈下降的趋势;DSC测试显示,支架材料中的GA链相对于LA链更易降解;FTIR图谱显示,PLGA组织工程支架材料的降解主要是酯键水解。

The degradable performances of PLGA tissue engineering scaffolds in NaCl water solution were studiel by measuring pH value of NaCl water solution, the lost weight rate of scaffolds, the molecular weight change of materials and analyzing FTIR and DSC spectra of scaffolds materials. We found that the molecular weight of scaffolds decreased with time; the weight of scaffolds did not always decrease with time; DSC spectra showed that the degradation of GA chains was easier than the degradation of LA chains; FTIR spectra showed that the degradation of ester bonds in PLGA was the main reason of PLGA;s degradation at 37℃ and with 160r/min surge rate.