多发性骨髓瘤患者骨桥蛋白升高的意义
摘要
广泛的溶骨性骨质破坏为多发性骨髓瘤（MM）特征性临床表现。这种骨质破坏的产生不仅与浆细胞的增殖或浸润有关，更与破骨细胞的激活有关。但其确切发病机制仍不清楚。骨桥蛋白（OPN）是一种分泌型磷酸化糖蛋白，在骨组织中与羟基磷灰石晶核结合并以基质沉淀形式存在。近来研究发现OPN在某些骨吸收病理状态下如类风湿关节炎、绝经后骨质疏松等起明显作用。
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2009年第4期268-269,共2页
Chinese Journal of Hematology
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