美能针配合化疗治疗妇科肿瘤的临床观察

Clincal oberservatian of strong neominophagen C injection in combination with chemotherapy in the treatment of gynecological tumors

目的观察美能注射液联合化疗治疗恶性肿瘤的疗效和毒副反应。方法将患者分为美能联合化疗组(治疗组)和单纯化疗组(对照组)进行疗效和毒副反应比较,统计方法以卡方检验。结果治疗组有效率58.3%(35/60),对照组有效率40.0%(24/60),两组比较有显著差异(P<0.05)。治疗组无肝功能损害,消化道反应占30.0%(18/60)程度轻,对照组肝功能损害占38.3%(23/60),消化道反应占43.3%(26/60)程度重。结论美能注射液联合化疗治疗恶性肿瘤,提高了疗效,预防药物性肝损害的发生,并减轻恶心、呕吐、乏力、食欲下降等其它消化道毒副反应的程度,提高患者的生存质量,值得推广。

Objective To observe the efficacy and toxic reactions of strong neominophagen C injection in combination with chemotherapy in the treatment of gynecological tumors. Methods The patients were assigned to receive chemotherapy in combination with strong neominophagen C injection （treatment group） or chemotherapy alone （control group）. The efficacy and adverse reactions of two groups were compared by chi-square test. Results The overall response rate （CR ＋ PR） were 58.3% （35/60）in the treatment group and 40.0% （24/60） in the control group, and significant differences were noted between two groups （ P 〈 0.05）. None of the patients in the treatment group were noted of hepatic lesion, but 38.3% （23/60） in the control group were noted of hepatic lesion ; and the gastrointestinal reactions in the treatment group were also less severe than in the control group, which were noted in 30. 0 % （18/60） in the treatment group and 43.3% （26/60） in the control group. Conclusion Strong neominophagen C injection plus chemotherapy can not only improve the curative effect, prevent drug -induced hepatic lesion, alleviate the gastrointestinal toxic reactions such as nausea, vomiting, anorexia and weakness, but also improve the life quality of patients withintermediate and end - stage gynecological tumors, which thus deserving to be widely used.