冠心病患者血小板蛋白激酶C活性的变化

Protein kinase C activity in platelets from coronary atherosclerotic heart disease

测定40例心绞痛（AP）、40例急性心肌梗死（AMI）患者及40例正常人（NC）的血小板胞膜、胞浆蛋白激酶C（PKC）活性。结果显示：AP和AMI组血小板胞膜中的PKC活性显著高于NC组（P＜0．01），而AP组高于AMI组（P＜0．05）；AP和AMI组血小板胞浆中PKC活性显著低于NC组（P＜0．01），而AP组低于AMI组（P＜0．05）。提示PKC可能与冠心病的发病有关。

The activity of protein kinase C(PKC)in membrane and cytosol of platelets in 40angina pectoris (AP)patients,40 acute myocardial infarction (AMI)patients and 40 normal control (NC)were studied. Results:The PKC in cytosol of platelets in AP patients and AMI patients was higher than in NC(P <0. 01 ),and the PKC in membran of platelets in AP patients was higher than in AMI patients(P <0.05). The activity of PKC in cytosol of platelets in AP patients and AMl patients was lower than in NC (P <0. 01),and the activity of PKC in cytosol of platelets in AP patients was lower than in AMl patients. The results suggest that PKC is likely associated with the cause of coronary heart disease.