血清内脂素水平与妊娠期糖尿病患者糖代谢的关系研究(英文)

Relationship between Serum Visfatin Levels and Glycometabolism in Gestational Diabetes Mellitus

目的探讨血清内脂素水平与妊娠期糖尿病(GDM)患者糖代谢的关系。方法80例孕妇被分为GDM组和对照组,分别检测其Visfatin、空腹胰岛素(FIN)、空腹血糖(FBG)及服糖后1h、2h、3h血糖(1hPG、2hPG、3hPG)水平,计算胰岛素抵抗指数(HOMA-IR)。结果(1)GDM组visfatin、FPG、1hPG、2hPG、3hPG、HOMA-IR、FIN水平明显高于对照组(P<0.01)。(2)GDM组血清内脂素水平与HOMA-IR、2hPG均有明显相关性(P均<0.01)。多元线性逐步回归分析表明,2hPG是影响血清内脂素的独立相关因素。结论GDM患者血清内脂素水平升高,可能是机体针对GDM患者体内血糖增高所发生的一种代偿效应。

Objective To investigate the relationship between serum visfatin levels and glycometabolism in gestational diabetes mellitus （GDM）. Methods 80 cases pregnant women were divided into two groups： GDM group and normal glucose tolerance group （control group）. The levels of serum visfatin, fast insulin（ FIN ）, fast plasma glucose（ FPG ）, 1 h, 2h, 3h plasma glucose after glucose loading（ 1 hPG, 2hPG、3hPG ） were measured. Insulin resistance index（HOMA-IR ） was calculated. Results （1）The levels of visfatin,FPG,1hPG,2hPG,3hPG,HOMA-IR, FIN were significantly higher in GDM group than control group（P〈 0.01 ）. （2）There was a positive correlation between visfatin and HOMA-IR and 2hPG（P〈 0.01 ）. Multiple regression analysis showed that 2hPG was independent related factor. Conclusion Increased serum levels of visfatin represents a compensatory mechanism aimed at high glucose levels in women with GDM.