苯磺酸氨氯地平治疗老年性高血压62例的疗效观察

Observation on the Therapeutic Effect of the Amlodipine Besylate Tablets in 62 Patients with Geriatric Hypertension

目的观察苯磺酸氨氯地平治疗老年性高血压的临床疗效。方法选择我院收治的老年性高血压病人62例,每日晨起口服苯磺酸氨氯地平片2.5mg,采用逐渐增量的方法,最大剂量5mg/d,疗程为4周,采用自身对照方法观察病人服用苯磺酸氨氯地平片后血压的变化。结果治疗4周后,血压由(165.8±14.5)(/105.2±8.5)mmHg降至(134.2±11.8)(/84.3±6.4)mmHg,差异有统计学意义(P<0.05),显效44例(70.97%),有效12例(19.35%),总有效率为90.32%,不良反应发生率为6.45%。结论苯磺酸氨氯地平是治疗老年性高血压的一种有效、安全、依从性好的药物。

Objective To observe the therapeutic effect of the amlodipine besylate tablets in patients with geriatric hypertension. Methods Sixty two patients with elder primary hypertension were treated by gradual increment from 2.5mg to 5mg everyday in 4weeks. Before and aftertreatment, clinical data were analysed. Results After 4 weeks, the hypertension was lower（ 134.2 ± 11.8 ）/（84.3 ± 6.4）mmHg, than before （165.8 ± 14.5 ）/（ 105.2 ± 8.5）mmHg（P〈 0.05）. The proportion of effection is 70.97% ,in all 90.32% ,the side reaction was 6.45%. Conclusion The amlodipine besylate tablets is secure and effective medicine to drop the blood pressure.It is obviously in elder patients of hypertension by this treatment.